ENDOWAY
ENDOWAY
ENDOMETRIOSIS AND MENSTRUAL PAIN
Endometriosis is a common disease in women of
reproductive age and the severity of the disease
is diverse (J.-Y. Kwack et al, 2016). Endometriosis
is defined as the presence of endometrium in an
abnormal or ectopic location. Histologically, it is
the presence of endometrial-like tissue or glands
outside the uterine cavity. It is a gynecological
disorder hormone dependent observed most
commonly in reproductively active women .
SYMPTOMS OF ENDOMETRIOSIS
Endometriosis may be asymptomatic, but most of
the time pain is the main symptom, especially during
menstruation (dysmenorrhea).
Clinical manifestations of endometriosis include
dyspareunia, cyclic menstrual pain, chronic pelvic
pain, and dyschezia, all of which can affect the
patient’s quality of life and health severely.
In all cases, the quality of life is diminished, both
physically and psychologically. The treatment of
pain is therefore an important issue. Morever, it is
often accompanied by infertility.
The estimated prevalence among women of
reproductive age is as high as 10%. Different studies
suggest that 20% to 50% of infertile women suffer
from endometriosis and from that 30% to 50% of
women with endometriosis are sub-fertile or infertile.
CAUSES OF ENDOMETRIOSIS
The abnormal presence of these endometrial cells at
different sites and organs could be explained by various
theories. It is widely accepted that underlying process
leading to endometriosis development is retrograde
menstruation, which is an antiperistaltic passage of
menstrual debris through Fallopian tubes.
It has been proven though, that retrograde
menstruation is a quite frequent phenomenon that occurs also in women without endometriosis.
Therefore, other factors are involved, including
a favourable endocrine, metabolic environment,
epithelial-mesenchymal transition, altered immunity,
inflammatory responses in genetically susceptible
women.
ENDOWAY: GOOD NUTRIENTS USEFUL
AGAINST ENDOMETRIOSIS PAINS
Endoway composition
Nutritional composition 2 capsules
Turmeric optimized Longvida®
– Of which curcumin
Broccoli BroccoRaphaninTM
– Of which glucoraphanin
Zinc picolinate
– Of which zinc element
Natural Vitamins E
Tocopherols
Active vitamin B6
Active vitamin B9
Vitamin D3
*Daily reference reports.
ENDOWAY: MODES OF ACTION OF THE
ACTIVE INGREDIENTS
Optimized curcumin longvida®
Longvida® is a patented, finely-tuned lipophilic
matrix brought together in a gentle, multi-step
process. The end product preserves and protects
the curcumin from the harsh environment of the
stomach, dissolves it at the point of absorption in
the GI tract, and delivers the free form of curcumin
(also called intact or native curcumin) into the blood
stream and target tissues.
Avantages of optimized curcumin longvida®
At least 65x more bioavailable than
traditional curcumin
Well tolerated and digested!
Crosses the blood-brain barrier to reach the
brain!
Without piperine from pepper (no interaction
with liver functions)
First of all, it is important to know that curcumin could
benefit any which inflammatory disease (Jurenka
JS, 2009). However, it has other properties that
could specifically target the pathophysiological
mechanisms of endometriosis. We have several
studies, in vitro and animal, that highlight its antiendometriosis
potential.
Higher levels of estradiol-17 β (E2) have been reported
in menstrual blood of endometriosis patients, in
comparison with healthy women (Takahashi K et
al, 1989). A study showed that curcumin was able
to suppress the proliferation of endometrial cells by
reducing E2 level.
Another study showed that Curcumin at a dose of
48 mg/kg b.w. repressed the MMP-2 activity via upregulation
of bound TIMP-2 expression, thus delayed
endometriosis development.
Curcumin treatment regressed also endometriosis
by inhibiting NFκB translocation and MMP-
3 expression. It also accelerated apoptosis in
endometriomas predominantly via cytochrome-c
mediated mitochondrial pathwa.
Curcumin administered to mice either post- or preendometriosis
arrested endometriosis in a dosedependent
way. It inhibited both MMP-9 activity and its
expression at the level of secretion, during regression
of endometriotic lesion. In addition, the attenuated
activity of MMP-9 was associated with decreased
expression of tumor necrosis factor-alpha (TNF-alpha)
during healing, suggesting the anti-inflammatory
property of curcumin.
Broccoli BroccoRaphaninTM
BroccoRaphaninTM broccoli extract is a highly
concentrated source of glucoraphanine, a precursor
to sulforaphane, a sulphur-rich component. This
extract comes from a unique process that opimizes
the conservation of essential components: minimum
10% glucoraphanine.
The latter would have the property of reducing
prostaglandin E2 highly inflammatory by inhibiting
microsomal prostaglandin E synthase 1. Broccoli extract also contains Indol 3
Carbinol (I3C), a molecule that increases levels of
non-estrogenic 2-hydroxyestrone and decreases
the level of highly estrogen-16-alpha-hydroxyestrone.
Zinc picolinate
Picolinate is the best assimilated form of zinc. A study
included 86 women showed that serum zinc levels
in women with endometriosis are decreased and
this seems to actually confirm that this microelement
can possibly affect the multifactorial pathogenesis
of the disease. In all cases it plays essential roles in immunity and inflammation
management.
Natural Vitamins E Tocopherols
In a clinical study, fifty-nine women, ages 19 to 41
years, with pelvic pain and history of endometriosis or
infertility were recruited. They have either received
an antioxidant supplement (vitamins C and E) or a
placebo for 8 weeks. The results of this clinical trial
show that administration of antioxidants reduces
ADVICE FOR USE
1 to 2 capsules per day with water, during meals.
Outside menstruation (if amenorrhea):
Take one Endoway capsule per day, on demand,
or continuously, especially for women who have a
treatment that stops menstruation.
During menstruation:
Take into account the fluidifying action of curcumin on
the blood, especially in case of heavy menstruation.
In this case, provide sufficient protection or stop
during menstruation in favour of ginger.
Contra-indication
Anyone with a hypothyroid or thyroid treatment
should first consult their doctor (broccoli).
Not recommended for people on anticoagulants
(curcumin).